A structural image of the B.1.1.7 COVID-19 variant published by University of B.C. researchers. (UBC)

A structural image of the B.1.1.7 COVID-19 variant published by University of B.C. researchers. (UBC)

UBC researchers capture first images of rapidly spreading B.1.1.7 COVID variant

Researchers believe current COVID vaccines will still work on U.K. variant

Researchers at the University of B.C. have created their image of a mutation on the SARS-CoV-2 spike protein that they believe is partly responsible for the B.1.1.7 variant.

The variant, known as the U.K. variant, has begun to make up the majority of new COVID-19 cases both in B.C. and around the country. According to federal data, there have been 4,039 cases of the B.1.1.7 variant in B.C. as of May 3.

The images were taken at a near-atomic resolution with a cryo-electron microscope – essentially, the imaging of samples at liquid nitrogen temperatures – and can provide information on why the variant is spreading so fast, according to Dr. Sriram Subramaniam, professor in UBC faculty of medicine’s department of biochemistry and molecular biology.

“The B.1.1.7 variant of concern, which was first reported to the World Health Organization in mid-December 2020, has an unusually large number of mutations,” Subramaniam said. “Of particular interest is a mutation known as N501Y located on the virus’s spike protein, which is what the virus uses to attach itself to human cells.”

That N501Y mutation is the only mutation in the B.1.1.7 variant located on the portion of the spike protein that binds to the human ACE2 receptor, which is the enzyme on the surface of our cells that serves as the entry gate for SARS-CoV-2.

The question is, will existing COVID-19 vaccines – given to more than 40 per cent of British Columbians – remain effective in the face of the variant?

“Our analysis revealed that even though the N501Y mutant can bind and enter our cells more readily, it can still be neutralized by antibodies that block the entry of the unmutated version of the virus into cells,” Subramaniam said, adding that he is also examining other variants, including the P.1 (Brazilian), B.1.351 (South African), B.1.427/B.1.429(Californian) and B.1.617 (Indian) variants.

“It’s important to understand the different molecular structures of these emerging variants to determine whether they’ll respond to existing treatments and vaccines and ultimately find ways to control their spread more effectively,” he said.

READ MORE: COVID-19 modelling shows B.C. bending the curve of variant cases

READ MORE: ‘Perfect storm’ of variants, increasing COVID cases are concerning for Surrey fire chief


@katslepian

katya.slepian@bpdigital.ca

Like us on Facebook and follow us on Twitter.

CoronavirusUBC

Just Posted

Grand Forks Fire/Rescue volunteers doused a hillside fire late Monday night, May 17. Photo: Laurie Tritschler
Grand Forks Fire/Rescue puts out hillside fire

No one was injured after a campfire got out of control below Columbia Drive

Michelle Jacobs receives her first dose of the COVID-19 vaccine at the Coast Capri Hotel on April 28, 2021. The pop-up clinic was hosted by the First Nations Health Authority. (Aaron Hemens/Capital News)
126 new cases of COVID-19 in Interior Health over the weekend

There are 22 individuals hospitalized due to the virus, and 13 in intensive care

View of the red SUV down an embankment. Photo: Trail RCMP
High speed crash sends 4 people to Trail hospital

The collision happened May 14 at the intersection of Highway 3B and Devito Drive

Lauren Regula
Trail native comes back for a third Olympic Games

Trail native Lauren Regula is proud to represent her country in softball at Tokyo Olympic Games

X
Trail RCMP issue BOLO for Solo

Solo was last spotted in Warfield, but has also been seen around the Tadanac area.

An avalanche near Highway 1 in Glacier National Park. Avalanche Canada will benefit from a $10 million grant from the B.C. government. (Photo by Parks Canada)
Avalanche Canada receives $10-million grant from B.C. government

Long sought-after funds to bolster organization’s important work

The top photo is of a real carbine rifle, while the bottom photo is the airsoft rifle seized from a Kelowna man on May 15. (Contributed)
RCMP issue warning: ‘Imitation firearms need to be dealt with responsibly’

A man brandishing his airsoft rifle in public had his weapon seized by Mounties on Saturday

Abbotsford Regional Hospital. (Black Press Media files)
Canada marks 25,000 COVID-19 deaths since the pandemic began

6 in every 10,000 Canadians died of COVID-19 since March 9, 2020

Staff-Sgt. Svend Nielsen, with the 100 Mile House RCMP. (Melissa Smalley - 100 Mile Free Press)
14-year-old boy killed in serious ATV crash near 100 Mile House

Youth was travelling with a group of peers when the incident occurred last Friday

Relief is coming for B.C.’s struggling tourism sector. (NEWS file photo)
B.C. officials set to announce more support for tourism sector hit hard by pandemic

Non-essential travel is restricted between three regional zones in B.C. until at least May 24

This image released by Universal Pictures shows Nathalie Emmanuel, left, and Vin Diesel in a scene from “F9.” (Giles Keyte/Universal Pictures via AP)
The blockbuster movie is making a comeback this summer

Excitement in the industry is growing again for a return to a big-screen normal

Grand Forks Fire/Rescue’s Dave Paulett hoses down a section of a wooden retaining wall which caught fire Monday, May 17. Photo: Laurie Tritschler
Fire starts in Grand Forks backyard after by oily rags left in sun

Flames put out before reaching home on 800-block of 72nd Avenue

Sicamous RCMP Sgt. Murray McNeil and Cpl. Wade Fisher present seven-year-old Cody Krabbendam of Ranchero with an award for bravery on July 22, 2020. (Contributed)
7-year old Shuswap boy receives medal of bravery for rescuing child at beach

Last summer Cody Krabbendam jumped into the lake to save another boy from drowning

B.C. Health Minister Adrian Dix and provincial health officer Dr. Bonnie Henry update the province’s COVID-19 vaccine program, May 10, 2021. (B.C. government)
B.C.’s COVID-19 infection rate stays below 500 a day over weekend

14 more deaths, down to 350 in hospital as of Monday

Most Read